Yes — and here is the hormonal reason
In the final days before menstruation, both estrogen and progesterone drop sharply. Estrogen supports neuromuscular efficiency — how effectively your nervous system recruits muscle fibers for a given lift — so when it falls, the same weight can genuinely require more effort to move, independent of your actual strength or fitness level. This is not you being weak. It is a measurable, temporary shift in neuromuscular output.
What is happening to your nervous system and muscles
Alongside reduced neuromuscular efficiency, falling progesterone also reduces its mild GABA-supported calming effect, which can leave the nervous system feeling more reactive and less coordinated for max-effort lifts specifically. Combined with common premenstrual fluid retention and disrupted sleep, the days right before your period are genuinely one of the least reliable windows for testing a new personal best.
What to do instead of pushing through
Rather than forcing a heavy top set in this window, it is usually more productive to shift toward moderate loads, higher reps, or technique-focused work, and save true strength testing for the follicular phase when estrogen is rising and neuromuscular output is at its best. This does not mean skipping training in the premenstrual days — it means choosing the right kind of effort for what your body can genuinely deliver that week. At Zōē, this is planned in advance rather than discovered mid-session.
Alongside Andreea and Francesco's direct coaching, The Zōē Method includes access to Mr Z — an AI coaching assistant built by Francesco Zen on ZTraining's 18-year coaching methodology, available via Telegram between sessions for real-time questions on training days, travel, and nutrition choices.
Andreea Mighiu is a women's hormonal health educator and the founder of Zōē. She works alongside a registered dietitian and an endocrinologist to ensure content reflects current clinical understanding. She is an educator, not a physician — Zōē's content is designed to inform, not to replace personalised medical advice.